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Journal / Immunology and Infection / Antibiyotik Direnci Platformu Kullanarak…
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Immunology and Infection

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JoVE Journal Immunology and Infection
Antibiyotik Direnci Platformu Kullanarak Antibiyotik Dereplication
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Antibiyotik Direnci Platformu Kullanarak Antibiyotik Dereplication

Article DOI: 10.3791/60536-v • 10:49 min • October 17th, 2019
October 17th, 2019 •
1, 2, 1
1Department of Biochemistry and Biomedical Sciences, M.G. DeGroote Institute for Infectious Disease Research, McMaster University, 2Department of Molecular and Cellular Biology, University of Guelph

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Biz antibiyotik dereplication için izojenik antibiyotiğe dirençli Escherichia coli bir kütüphane kullanan bir platform açıklar. Bakteri veya mantarlar tarafından üretilen bir antibiyotiğin kimliği, kendi direnç genini ifade eden E. coli'nin büyümesi ile ortaya çıkarılabilir. Bu platform ekonomik açıdan etkili ve zaman etkindir.

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İmmünoloji ve Enfeksiyon Sayı 152 antibiyotik dereplik ilaç keşfi aktinomisetitler Escherichia coli,sekonder metabolit direnç enzimleri doğal ürün
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