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Immunology and Infection

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In Vivo Augmentation of Gut-Homing Regulatory T Cell Induction
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In Vivo Augmentation of Gut-Homing Regulatory T Cell Induction

Article DOI: 10.3791/60585-v • 08:02 min • January 22nd, 2020
January 22nd, 2020 •
1,2, 1, 1, 1,3,4, 1,3
1Division of Regenerative Medicine, Department of Medicine, Loma Linda University, 2Zhengzhou University, 3Department of Veterinary Biomedical Sciences, College of Veterinary Medicine, Long Island University, 4Jinan Infectious Disease Hospital, Shandong University

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Ici nous présentons un protocole pour l'augmentation in vivo de l'induction réglementaire de cellule T d'intestin-homing. Dans ce protocole, les cellules dendritiques sont conçues pour produire localement des concentrations élevées de la vitamine Active D (1,25-dihydroxyvitamin D ou 1,25[OH]2D) et de la vitamine A active (acide rétinoïque ou RA) de novo.

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Immunologie et infection numéro 155 cellules T régulatrices intestinales 25-hydroxyvitamin D 1-hydroxylase famille cytochrome P450 27 membres de la sous-famille B 1 1,25-dihydroxyvitamin D foxp3 cellules dendritiques rétinien dégénéolase 2 récepteur c-c c chemokine type 9
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