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Journal / Chemistry / 18 ans, états-unis qui F-Labeling of Radiotracers …
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JoVE Journal Chemistry
18 ans, états-unis qui F-Labeling of Radiotracers Functionalized with a Silicon Fluoride Acceptor (SiFA) for Positron Emission Tomography
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18 ans, états-unis qui F-Labeling of Radiotracers Functionalized with a Silicon Fluoride Acceptor (SiFA) for Positron Emission Tomography

Article DOI: 10.3791/60623-v • 09:57 min • January 11th, 2020
January 11th, 2020 •
*1, *1, 2,3, 2,3, 4, 5, 1, 1, 1
1Department of Oncology, University of Alberta, 2Department of Nuclear Medicine, University Hospital of Munich, 3ENETS Centre of Excellence, Interdisciplinary Center of Neuroendocrine Tumors of the GastroEnteroPancreatic System, LMU Munich, 4Biomedical Chemistry, Department of Clinical Radiology and Nuclear Medicine, Medical Faculty Mannheim of Heidelberg University, 5Molecular Imaging and Radiochemistry, Department of Clinical Radiology and Nuclear Medicine, Medical Faculty Mannheim of Heidelberg University
* These authors contributed equally

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La synthèse des produits radiopharmaceutiques étiquetés fluor-18(18F) pour la tomographie par émission de positrons nécessite généralement des mois d'expérience. Lorsqu'il est incorporé dans un radiotraceur, le motif de l'accepteur de silicium-fluorure (SiFA) permet un simple protocole d'étiquetage F 18indépendant de l'équipement coûteux et de la formation préparatoire, tout en réduisant la quantité de précurseurs nécessaire et en utilisant des conditions de réaction plus douces.

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Chimie Numéro 155 18F-radiolabeling radiotracer imagerie in vivo tomographie par émission de positons (TEP) fluor-18 accepteur de silicium-fluorure (SiFA)
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