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Journal / Chemistry / 18 F-mærkning af Radiotracers Funktionaliseret…
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JoVE Journal Chemistry
18 F-mærkning af Radiotracers Funktionaliseret med en silicium fluorid acceptor (SiFA) for Positron emission Tomography
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18 F-mærkning af Radiotracers Funktionaliseret med en silicium fluorid acceptor (SiFA) for Positron emission Tomography

Article DOI: 10.3791/60623-v • 09:57 min • January 11th, 2020
January 11th, 2020 •
*1, *1, 2,3, 2,3, 4, 5, 1, 1, 1
1Department of Oncology, University of Alberta, 2Department of Nuclear Medicine, University Hospital of Munich, 3ENETS Centre of Excellence, Interdisciplinary Center of Neuroendocrine Tumors of the GastroEnteroPancreatic System, LMU Munich, 4Biomedical Chemistry, Department of Clinical Radiology and Nuclear Medicine, Medical Faculty Mannheim of Heidelberg University, 5Molecular Imaging and Radiochemistry, Department of Clinical Radiology and Nuclear Medicine, Medical Faculty Mannheim of Heidelberg University
* These authors contributed equally

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Syntesen af fluor-18 (18F) mærkede radioaktive lægemidler til Positron emission tomografi typisk kræver måneders erfaring. Når Silicon-fluorid acceptor (SiFA)-motivet inkorporeres i et radiotracer, muliggør det en simpel 18F-mærknings protokol, der er uafhængig af dyrt udstyr og forberedende træning, samtidig med at det er nødvendigt at reducere prækursorer og udnytte mildere reaktionsbetingelser.

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Kemi 18F-radioaktiv mærkning radiotracer in vivo Imaging Positron emission tomografi (PET) fluor-18 silicium-fluorid acceptor (sifa)
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