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Flerdimensjonal kokultur system for å modellere lungeplatekarsinom progresjon
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Flerdimensjonal kokultur system for å modellere lungeplatekarsinom progresjon

Article DOI: 10.3791/60644-v • 07:53 min • March 17th, 2020
March 17th, 2020 •
1, 1, 1, 1
1Oncology R&D group, Pfizer Worldwide Research and Development

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Et in vitro-modellsystem ble utviklet for å fange vevarkitektoniske endringer under lungeplatekarsinom (LUSC) progresjon i en 3-dimensjonal (3D) co-kultur med kreft-assosierte fibroblaster (CAFs). Dette organoidsystemet gir en unik plattform for å undersøke rollene til ulike tumorcelle-iboende og ekstriniske endringer som modulerer tumorfenotypen.

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Kreftforskning Utgave 157 3D-kokultur lungekreft kreftassosierte fibroblaster acinar morfose tumororganoider
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