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Identificering af hæmmere af HBx-DDB1-interaktionen ved hjælp af et split luciferase-analyse system
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Identificering af hæmmere af HBx-DDB1-interaktionen ved hjælp af et split luciferase-analyse system

Article DOI: 10.3791/60652-v • 05:55 min • December 21st, 2019
December 21st, 2019 •
1,2, 1, 1
1Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 2Research Fellow of Japan Society for the Promotion of Science

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Her præsenterer vi en metode til screening anti-hepatitis B viral agenter, der hæmmer HBX-DDB1 interaktion ved hjælp af en split der assay system. Dette system giver mulighed for nem påvisning af protein-protein interaktioner og er egnet til at identificere hæmmere af sådanne interaktioner.

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Medicin hepatitis B-virus lægemiddel screening højt gennemløb virus-Host interaktion Smc5/6 protein-protein interaktion nitazoxid
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