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Journal / Medicine / 四塩化炭素(CCl4)を介したラットの急性肝損傷を誘発する(CCl4)オロ胃管による暴露…
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四塩化炭素(CCl4)を介したラットの急性肝損傷を誘発する(CCl4)オロ胃管による暴露
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四塩化炭素(CCl4)を介したラットの急性肝損傷を誘発する(CCl4)オロ胃管による暴露

Article DOI: 10.3791/60695-v • 06:12 min • April 28th, 2020
April 28th, 2020 •
*1, *1, 2, 3, 1, 1, 4, 1, 1, 1
1Department of Anesthesiology and Critical Care, Soroka Medical Center, Ben-Gurion University of the Negev, 2Department of Anesthesiology, Yale University School of Medicine, 3Department of Neurosurgery, Soroka University Medical Center and the Faculty of Health Sciences, Ben-Gurion University of the Negev, 4Department of Ophthalmology, Soroka University Medical Center and the Faculty of Health Sciences, Ben-Gurion University of the Negev
* These authors contributed equally

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このプロトコルは、オロ胃管を介してCCl4曝露を介して急性肝傷害(ALI)を誘発する一般的かつ実現可能な方法を記述する。CCl4曝露は、肝臓におけるその生体変換中に活性酸素種の形成を通じてALIを誘導する。この方法は、ALIの病態生理を分析し、異なる肝保護戦略を調べるために使用されます。

Tags

医学、158号、急性肝損傷(ALI)、四塩化炭素(CCl4)、肝損傷、肝臓損傷、ラットモデル、毒素
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