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Indusere akutt leverskade hos rotter via karbon tetrachloride (CCl4) Eksponering gjennom et orogastrisk rør
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Indusere akutt leverskade hos rotter via karbon tetrachloride (CCl4) Eksponering gjennom et orogastrisk rør

Article DOI: 10.3791/60695-v • 06:12 min • April 28th, 2020
April 28th, 2020 •
*1, *1, 2, 3, 1, 1, 4, 1, 1, 1
1Department of Anesthesiology and Critical Care, Soroka Medical Center, Ben-Gurion University of the Negev, 2Department of Anesthesiology, Yale University School of Medicine, 3Department of Neurosurgery, Soroka University Medical Center and the Faculty of Health Sciences, Ben-Gurion University of the Negev, 4Department of Ophthalmology, Soroka University Medical Center and the Faculty of Health Sciences, Ben-Gurion University of the Negev
* These authors contributed equally

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Denne protokollen beskriver en vanlig og gjennomførbar metode for å indusere akutt leverskade (ALI) via CCl4 eksponering gjennom et orogastrisk rør. CCl4 eksponering induserer ALI gjennom dannelsen av reaktive oksygenarter under biotransformasjon i leveren. Denne metoden brukes til å analysere patofysiologien til ALI og undersøke forskjellige hepatoprotektoriske strategier.

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Medisin Utgave 158 akutt leverskade (ALI) karbontetrachlorid (CCl4) leverskade leverskade rottemodell toksin
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