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Validert LC-MS/MS-panel for kvantifisering av 11 legemiddelresistente TB-medisiner i små hårprøver

Article DOI: 10.3791/60861-v • 08:54 min • May 19th, 2020
May 19th, 2020 •
1, 1, 1, 2, 3, 4, 1
1Department of Obstetrics, Gynecology and Reproductive Sciences, TB Hair Analysis Laboratory, University of California San Francisco, 2Department of Epidemiology and Biostatistics, University of California San Francisco, 3Department of Medicine, Division of HIV, Infectious Diseases, and Global Medicine, University of California San Francisco, 4Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of California San Francisco

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Nåværende metoder for å analysere pasientenes overholdelse av komplekse legemiddelresistente-tuberkuloseregimer (DR-TB) kan være unøyaktige og ressursintensive. Vår metode analyserer hår, en lett samlet og lagret matrise, for konsentrasjoner av 11 DR-TB medisiner. Ved hjelp av LC-MS/MS kan vi bestemme subnanogram legemiddelnivåer som kan brukes til å forstå legemiddeloverholdelse naviss.

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Medisin Utgave 159 LC-MS/MS MDR-TB-legemidler Håranalyse Oppfølgingsovervåking Terapeutisk legemiddelovervåking Legemiddelresistent tb
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