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Painel LC-MS/MS validado para quantificar 11 medicamentos resistentes a medicamentos para tuberculose em amostras de cabelos pequenos
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Painel LC-MS/MS validado para quantificar 11 medicamentos resistentes a medicamentos para tuberculose em amostras de cabelos pequenos

Article DOI: 10.3791/60861-v • 08:54 min • May 19th, 2020
May 19th, 2020 •
1, 1, 1, 2, 3, 4, 1
1Department of Obstetrics, Gynecology and Reproductive Sciences, TB Hair Analysis Laboratory, University of California San Francisco, 2Department of Epidemiology and Biostatistics, University of California San Francisco, 3Department of Medicine, Division of HIV, Infectious Diseases, and Global Medicine, University of California San Francisco, 4Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of California San Francisco

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Os métodos atuais de análise da adesão dos pacientes a regimes complexos de tuberculose resistente a medicamentos (DR-TB) podem ser imprecisos e intensivos em recursos. Nosso método analisa o cabelo, uma matriz facilmente coletada e armazenada, para concentrações de 11 medicamentos DR-TB. Usando LC-MS/MS, podemos determinar níveis de drogas de sub-nanogramas que podem ser utilizados para entender melhor a adesão aos medicamentos.

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Medicina Edição 159 LC-MS/MS Medicamentos MDR-TB Análise capilar Monitoramento de Adesão Monitoramento de Medicamentos Terapêuticos TB resistente a medicamentos
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