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Journal / Developmental Biology / Generazione di un chip di barriera…
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Developmental Biology

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JoVE Journal Developmental Biology
Generazione di un chip di barriera emato-encefalica basata sull'iPSC umano
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Generazione di un chip di barriera emato-encefalica basata sull'iPSC umano

Article DOI: 10.3791/60925-v • 10:20 min • March 2nd, 2020
March 2nd, 2020 •
1,2,3, 4, 5,6, 4, 1,2,3
1The Department of Physiology and Cell Biology, Faculty of Health Sciences, Ben-Gurion University of the Negev, 2The Regenerative Medicine and Stem Cell (RMSC) Research Center, Ben-Gurion University of the Negev, 3The Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, 4The Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, 5Division of Micro and Nanosystems, KTH Royal Institute of Technology, 6AIMES, Department of Neuroscience, Karolinska Institutet

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La barriera emato-encefalica (BBB) è un'unità neurovascolare multicellulare che regola strettamente l'omeostasi cerebrale. Combinando gli iPSC umani e le tecnologie organ-on-chip, abbiamo generato un chip BBB personalizzato, adatto per la modellazione delle malattie e le previsioni di penetrazione dei farmaci del SNC. Viene descritto un protocollo dettagliato per la generazione e il funzionamento del chip BBB.

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Biologia dello sviluppo numero 157 barriera ematoencefalica BBB microfluidica organo su chip OoC unità neurovascolare NVU iPSC cellule iPS astrociti medicina personalizzata medicina di precisione
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