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Journal / Biology / C. elegans RAN Peptid Toksisitesi Ölçme
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C. elegans RAN Peptid Toksisitesi Ölçme
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C. elegans RAN Peptid Toksisitesi Ölçme

Article DOI: 10.3791/61024-v • 10:49 min • April 30th, 2020
April 30th, 2020 •
1, 2, 2, 1,2
1Graduate Program in Cell Biology and Molecular Physiology, University of Pittsburgh, 2Department of Pediatrics, University of Pittsburgh School of Medicine

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Tekrarla ilişkili olmayan ATG bağımlı çeviri ürünleri, tekrarlayan genişleme tabanlı hastalıkların patojenik özellikleridir. Açıklanan protokolün amacı, c. elegansmodel sisteminde davranışsal ve hücresel tahliller kullanarak bu peptidlerin neden olduğu toksisiteyi değerlendirmektir.

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Biyoloji Sayı 158 nörodejenerasyon ALS Huntington hastalığı C9orf72 proteotoksisite tekrar genleşme bozuklukları
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