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An Image Guided Transapical Mitral Valve Leaflet Puncture Model of Controlled Volume Overload from Mitral Regurgitation in the Rat
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An Image Guided Transapical Mitral Valve Leaflet Puncture Model of Controlled Volume Overload from Mitral Regurgitation in the Rat

Article DOI: 10.3791/61029-v • 07:42 min • May 19th, 2020
May 19th, 2020 •
1, 1, 1, 1,2
1Structural Heart Research and Innovation Laboratory, Carlyle Fraser Heart Center, Emory University Hospital Midtown, 2Division of Cardiothoracic Surgery, Joseph P. Whitehead Department of Surgery, Emory University School of Medicine

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Summary
Automatic Translation

A rodent model of left heart volume overload from mitral regurgitation is reported. Mitral regurgitation of controlled severity is induced by advancing a needle of defined dimensions into the anterior leaflet of the mitral valve, in a beating heart, with ultrasound guidance. 

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Mitral Regurgitation Heart Failure Rat Model Valve Disease Volume Overload Controlled Volume Overload Image-guided Technique Echocardiographic Imaging Needle Placement Thoracotomy Suture Microneedle Holder Left Ventricle Transesophageal Echo Probe Ultrasound Guidance
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