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Semi-Minimal Invasive Method to Induce Myocardial Infarction in Rats and the Assessment of Cardiac Function by an Isolated Working Heart System
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Medicine
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JoVE Journal Medicine
Semi-Minimal Invasive Method to Induce Myocardial Infarction in Rats and the Assessment of Cardiac Function by an Isolated Working Heart System

Semi-Minimal Invasive Method to Induce Myocardial Infarction in Rats and the Assessment of Cardiac Function by an Isolated Working Heart System

DOI:
10.3791/61033-v

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08:01 min

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June 11, 2020

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, , , , , , , , ,
1Ludwig-Boltzmann-Institute for Cardiovascular Research at the Center for Biomedical Research,Medical University of Vienna, 2Concept & Ideation, Electrical Sector/EMEA/Power Distribution Division,Eaton Industries (Austria) GmbH, 3Vetfarm and Clinical Unit for Herd Health Management in Ruminants, Clinic for Ruminants,Vetmeduni Vienna

Chapters

  • 00:04Introduction
  • 01:29Induction of Myocardial Ischemia
  • 03:41Echocardiography Measurements and Organ Harvesting
  • 05:03Ex Vivo Hemodynamic Measurements via a Working Heart System
  • 06:15Results: Effects of Remote Ischemic Conditioning
  • 07:17Conclusion

Summary

Automatic Translation

Automatic Translation

This article presents an efficient method to perform myocardial ischemia and subsequent chronic reperfusion in rats using a minimally invasive approach. In addition, left ventricular hemodynamic function of rats is assessed by echocardiography and isolated working heart methods. 

Tags

Myocardial InfarctionRat ModelSemi-minimal InvasiveIsolated Working Heart SystemLeft Anterior Descending Artery OcclusionIschemia-reperfusionCardiac Function Assessment

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