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Journal / Biochemistry / 分子動力学シミュレーションによるEGFR体型変異の活性化の構造効果の解読…
JoVE Journal
Biochemistry

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JoVE Journal Biochemistry
分子動力学シミュレーションによるEGFR体型変異の活性化の構造効果の解読
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分子動力学シミュレーションによるEGFR体型変異の活性化の構造効果の解読

Article DOI: 10.3791/61125-v • 15:05 min • May 20th, 2020
May 20th, 2020 •
1, 2, 2,3,4, 1
1Structural Bioinformatics Laboratory, Biochemistry, Faculty of Science and Engineering, Åbo Akademi University, 2Medicity Research Laboratories and Institute of Biomedicine, University of Turku, 3Turku Bioscience Centre, University of Turku and Åbo Akademi University, 4Department of Oncology and Radiotherapy, University of Turku and Turku University Hospital

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このプロトコルの目的は、分子動力学シミュレーションを用いて、EGFRキナーゼタンパク質の活性化変異に起因する動的構造変化を調べることである。

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今月のJoVE、問題159、分子動力学シミュレーション、タンパク質構造解析、上皮成長因子受容体ファミリー、体細胞変異、癌
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