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Caenorhabditis elegans gebruiken om te screenen op weefselspecifieke chaperonne-interacties
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Caenorhabditis elegans gebruiken om te screenen op weefselspecifieke chaperonne-interacties

Article DOI: 10.3791/61140-v • 06:55 min • June 7th, 2020
June 7th, 2020 •
1, 1, 1, 1
1Department of Life Sciences, Ben-Gurion University of the Negev

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Om chaperonne-chaperonne- en chaperonne-substraatinteracties te bestuderen, voeren we synthetische interactiescreenings uit in Caenorhabditis elegans met behulp van RNA-interferentie in combinatie met milde mutaties of overexpressie van chaperonnes en monitoren we weefselspecifieke eiwitdisfunctie op organismaal niveau.

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Biologie Nummer 160 Caenorhabditis elegans chaperonne genetische interacties proteostase RNAi scherm temperatuurgevoelig
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