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Immunology and Infection

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JoVE Journal Immunology and Infection
Vurdering af humane naturlige killer celle begivenheder drevet af FcγRIIIa Engagement i nærvær af terapeutiske antistoffer
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Vurdering af humane naturlige killer celle begivenheder drevet af FcγRIIIa Engagement i nærvær af terapeutiske antistoffer

Article DOI: 10.3791/61144-v • 09:54 min • May 22nd, 2020
May 22nd, 2020 •
1, 2, 1, 2, 1, 1, 1
1Department of Research and Development, iQ Biosciences, 2Department of Cellular Products, iQ Biosciences

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En protokol til undersøgelse af FcγRIIIa-drevne hændelser af terapeutiske antistoffer i menneskelige naturlige dræberceller er beskrevet her. Denne kunstige stimuleringsplatform gør det muligt at forhøre downstream-effektorfunktioner som degranulation, chemokin/cytokinproduktion og signalveje, der medieres af De Europæiske Forbindelser og Fc,som er forbundet med binding.

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Immunologi og infektion NK celler FcγRIIIa engagement terapeutiske antistoffer små molekyler genekspression degranulation cytokin frigivelse signalering
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