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Journal / Biochemistry / Triagem espectrofotométrica para potenciais…
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Biochemistry
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JoVE Journal Biochemistry
Triagem espectrofotométrica para potenciais inibidores de Glutathione Citosolítica S-Transferases
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Triagem espectrofotométrica para potenciais inibidores de Glutathione Citosolítica S-Transferases

Article DOI: 10.3791/61347-v • 14:57 min • October 10th, 2020
October 10th, 2020 •
1,2, *1,3, *1,3
1Research platform of Pediatric Onco-Hematology, Department of Paediatrics, Gynaecology and Obstetrics, Faculty of Medicine, University of Geneva, 2Section of Biology, Faculty of Science, University of Geneva, 3Onco-Hematology Unit, Department of Women, Children-Adolescents, University Hospitals of Geneva
* These authors contributed equally

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Glutationa S-transferases (GSTs) são enzimas desintoxicação envolvidas no metabolismo de numerosas drogas quimioterápicas. A superexpressão dos GSTs está correlacionada com a resistência à quimioterapia do câncer. Uma maneira de combater este fenótipo é usar inibidores. Este protocolo descreve um método usando um ensaio espectrofotométrico para rastrear potenciais inibidores GST.

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Bioquímica Edição 164 Glutathione S-transferases inibidores GST ensaio enzimático ensaio de inibição IC50 Ki
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