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Journal / Cancer Research / 为癌症药理学研究创建匹配的体内/体外患者衍生模型对 PDX 和 PDX…
JoVE Journal
Cancer Research

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JoVE Journal Cancer Research
为癌症药理学研究创建匹配的体内/体外患者衍生模型对 PDX 和 PDX 衍生器官
Obtaining Cancer Stem Cell Spheres from Gynecological and Breast Cancer Tumors
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Tumor Allotransplantation in Drosophila melanogaster with a Programmable Auto-Nanoliter Injector
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Tumor Allotransplantation in Drosophila melanogaster with a Programmable Auto-Nanoliter Injector
 
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为癌症药理学研究创建匹配的体内/体外患者衍生模型对 PDX 和 PDX 衍生器官

Article DOI: 10.3791/61382-v • 04:49 min • May 5th, 2021
May 5th, 2021 •
1, 1, 2, 2, 2, 1, 2, 2, 1, 2, 3, 2, 2, 2, 3
1Crown Bioscience Inc., Changping District, Beijing, China, 2Crown Bioscience Inc., Taicang, Jiangsu, China, 3Crown Bioscience Inc., San Diego, CA, USA

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描述使用患者衍生的异种格拉夫特 （PDX） 进行体外筛查的方法，从而形成匹配的体内/体外模型对。PDX 肿瘤被机械或酶地收获/加工成小块，然后是 Clevers 的生长肿瘤器官的方法，这些器官是通过、冷冻保存和针对原始 PDX 进行特征的。

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本月在JoVE，第171期，体外癌症模型，动物肿瘤模型，形态学，组织病理学，基因组分析，化疗
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