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Journal / Developmental Biology / In vitro Neuromusculaire Verbinding veroorzaakt…
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Developmental Biology

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JoVE Journal Developmental Biology
In vitro Neuromusculaire Verbinding veroorzaakt uit menselijke geïnduceerde pluripotente stamcellen
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In vitro Neuromusculaire Verbinding veroorzaakt uit menselijke geïnduceerde pluripotente stamcellen

Article DOI: 10.3791/61396-v • 06:01 min • December 3rd, 2020
December 3rd, 2020 •
1, 1,2, 3, 1
1Department of Clinical Application, Center for iPS Cell Research and Application (CiRA), Kyoto University, 2Department of Pediatrics, Kyoto Prefectural University of Medicine, 3Graduate Institute of Clinical Medicine, Taipei Medical University

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Hier bieden we een protocol om in vitro NMJs te genereren uit door de mens veroorzaakte pluripotente stamcellen (iPSC's). Deze methode kan NMJs met volwassen morfologie en functie in 1 maand in een enkele put induceren. De resulterende NMJ's kunnen mogelijk worden gebruikt om gerelateerde ziekten te modelleren, pathologische mechanismen te bestuderen of om geneesmiddelenverbindingen te screenen op therapie.

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Ontwikkelingsbiologie iPSCs in vitro neuromusculaire kruising motorneuron Schwann cel myotube contractie curare
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