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Journal / Immunology and Infection / Stabilität und Struktur der Fledermaus Haupt…
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Immunology and Infection

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JoVE Journal Immunology and Infection
Stabilität und Struktur der Fledermaus Haupt Histokompatibilität Komplex Klasse I mit heterologen β2-Mikroglobulin
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Stabilität und Struktur der Fledermaus Haupt Histokompatibilität Komplex Klasse I mit heterologen β2-Mikroglobulin

Article DOI: 10.3791/61462-v • 11:17 min • March 10th, 2021
March 10th, 2021 •
*1,2, *3,4, *2,5, 1,2, 1,2, 2, 2, 4, 1, 4, 1,2
1School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, 2NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, 3Faculty of Health Sciences, University of Macau, 4CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, 5Savaid Medical School, University of Chinese Academy of Sciences
* These authors contributed equally

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Das Protokoll beschreibt experimentelle Methoden zur Erlangung stabiler Haupthistokompatibilitätskomplexe (MHC) Klasse I durch potenzielle β 2-Mikroglobulin(β2m) Substitutionen verschiedener Arten. Untersucht wurde der strukturelle Vergleich von MHC I, der durch homologe und heterologe β2m stabilisiert wurde.

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Immunologie und Infektion Ausgabe 169 Haupthistokompatibilitäts-Antigenkomplex (MHC) Klasse I Moleküle β2-Mikroglobulin (β2m) komplexe Struktur Peptid TCR Tetramer
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