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Journal / Behavior / 使用振动轨道转子诱导年轻野生型小鼠认知缺陷和焦虑样行为的慢性睡眠碎片模型…
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Behavior

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JoVE Journal Behavior
使用振动轨道转子诱导年轻野生型小鼠认知缺陷和焦虑样行为的慢性睡眠碎片模型
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使用振动轨道转子诱导年轻野生型小鼠认知缺陷和焦虑样行为的慢性睡眠碎片模型

Article DOI: 10.3791/61531-v • 06:23 min • September 22nd, 2020
September 22nd, 2020 •
1, 1, 1, 1, 1, 1, 1, 1,2, 1,3
1Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, China, 2Key Laboratory of Neurological Diseases of Chinese Ministry of Education, The School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000,China, 3Department of Pharmacology, School of Basic Medical Science; State Key Laboratory of Medical Neurobiology, Institutes of Brain Science and Collaborative Innovation Center for Brain Science, Fudan University, Shanghai 200032, China

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Summary
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这里介绍的是一个由电控轨道转子实现的慢性睡眠碎片（CSF）模型的协议，它可以诱导年轻野生型小鼠的认知缺陷和类似焦虑的行为。该模型可用于探索慢性睡眠障碍和相关疾病的发病机制。

Tags

行为， 问题 163， 慢性睡眠分裂， 轨道转子， 认知缺陷， 焦虑样的行为， 阻碍睡眠呼吸暂停， 神经退行性疾病
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