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JoVE Journal Behavior
En kronisk søvnfragmenteringsmodell ved hjelp av vibrerende orbital rotor for å indusere kognitivt underskudd og angstlignende oppførsel hos unge villtypemus
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En kronisk søvnfragmenteringsmodell ved hjelp av vibrerende orbital rotor for å indusere kognitivt underskudd og angstlignende oppførsel hos unge villtypemus

Article DOI: 10.3791/61531-v • 06:23 min • September 22nd, 2020
September 22nd, 2020 •
1, 1, 1, 1, 1, 1, 1, 1,2, 1,3
1Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, China, 2Key Laboratory of Neurological Diseases of Chinese Ministry of Education, The School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000,China, 3Department of Pharmacology, School of Basic Medical Science; State Key Laboratory of Medical Neurobiology, Institutes of Brain Science and Collaborative Innovation Center for Brain Science, Fudan University, Shanghai 200032, China

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Presentert her er en protokoll for kronisk søvnfragmentering (CSF) modell oppnådd av en elektrisk kontrollert orbital rotor, som kan indusere bekreftet kognitivt underskudd og angst-lignende atferd i unge vill-type mus. Denne modellen kan brukes til å utforske patogenesen av kronisk søvnforstyrrelser og relaterte lidelser.

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Atferd Problem 163 kronisk søvnfragmentering orbital rotor kognitivt underskudd angstlignende atferd obstruktiv søvnapné nevrodegenerative sykdommer
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