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Funktionell bedömning av BRCA1-varianter med CRISPR-medierade basredigerare
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Funktionell bedömning av BRCA1-varianter med CRISPR-medierade basredigerare

Article DOI: 10.3791/61557-v • 09:22 min • February 28th, 2021
February 28th, 2021 •
1,2, 1,2, 1,2, 1,2, 1,2
1Department of Biomedical Sciences, Asan Medical Institute of Convergence Science and Technology, Asan Medical Center, University of Ulsan College of Medicine, 2Stem Cell Immunomodulation Research Center, University of Ulsan College of Medicine

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Personer med BRCA1-mutationer har en högre risk att utveckla cancer, vilket motiverar noggrann utvärdering av funktionen hos BRCA1-varianter. Häri beskrev vi ett protokoll för funktionell bedömning av BRCA1-varianter med CRISPR-medierade cytosinbasredigerare som möjliggör riktad C:G till T:A-konvertering i levande celler.

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Cancerforskning Utgåva 168 CRISPR-Cas basredigering BE3 BRCA1 funktionell bedömning Genomteknik
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