Waiting
Login processing...

Trial ends in Request Full Access Tell Your Colleague About Jove
Journal / Cancer Research / Funktionel vurdering af BRCA1-varianter ved hjælp …
JoVE Journal
Cancer Research

A subscription to JoVE is required to view this content.

JoVE Journal Cancer Research
Funktionel vurdering af BRCA1-varianter ved hjælp af CRISPR-medierede basiseditorer
Application of Laser Micro-irradiation for Examination of Single and Double Strand Break Repair in Mammalian Cells
Journal (Cancer Research)
Application of Laser Micro-irradiation for Examination of Single and Double Strand Break Repair in Mammalian Cells
A Genetically Engineered Mouse Model of Sporadic Colorectal Cancer
Journal (Cancer Research)
A Genetically Engineered Mouse Model of Sporadic Colorectal Cancer
 
Click here for the English version

Funktionel vurdering af BRCA1-varianter ved hjælp af CRISPR-medierede basiseditorer

Article DOI: 10.3791/61557-v • 09:22 min • February 28th, 2021
February 28th, 2021 •
1,2, 1,2, 1,2, 1,2, 1,2
1Department of Biomedical Sciences, Asan Medical Institute of Convergence Science and Technology, Asan Medical Center, University of Ulsan College of Medicine, 2Stem Cell Immunomodulation Research Center, University of Ulsan College of Medicine

Chapters

Summary
Automatic Translation

Please note that all translations are automatically generated.

Click here for the English version.

Mennesker med BRCA1 mutationer har en højere risiko for at udvikle kræft, hvilket berettiger præcis evaluering af funktionen af BRCA1 varianter. Heri beskrev vi en protokol til funktionel vurdering af BRCA1-varianter ved hjælp af CRISPR-medierede cytosinbaseredaktører, der muliggør målrettet C:G til T:A-konvertering i levende celler.

Tags

Kræftforskning Problem 168 CRISPR-Cas basisredigering BE3 BRCA1 funktionel vurdering Genomteknik
Read Article

Get cutting-edge science videos from JoVE sent straight to your inbox every month.

Waiting X
Simple Hit Counter