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Functionele beoordeling van BRCA1-varianten met CRISPR-gemedieerde basiseditors
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Functionele beoordeling van BRCA1-varianten met CRISPR-gemedieerde basiseditors

Article DOI: 10.3791/61557-v • 09:22 min • February 28th, 2021
February 28th, 2021 •
1,2, 1,2, 1,2, 1,2, 1,2
1Department of Biomedical Sciences, Asan Medical Institute of Convergence Science and Technology, Asan Medical Center, University of Ulsan College of Medicine, 2Stem Cell Immunomodulation Research Center, University of Ulsan College of Medicine

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Mensen met BRCA1-mutaties hebben een hoger risico op het ontwikkelen van kanker, wat een nauwkeurige evaluatie van de functie van BRCA1-varianten garandeert. Hierin beschreven we een protocol voor functionele beoordeling van BRCA1-varianten met behulp van CRISPR-gemedieerde cytosinebasiseditors die gerichte C:G naar T:A-conversie in levende cellen mogelijk maken.

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Cancer Research CRISPR-Cas base editing BE3 BRCA1 functionele beoordeling Genome engineering
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