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Journal / Neuroscience / 渗透泵的植入和压力的诱导，以建立一个症状，药理学小鼠模型DYT/PARK-ATP1A3肌张…
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Neuroscience
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JoVE Journal Neuroscience
渗透泵的植入和压力的诱导，以建立一个症状，药理学小鼠模型DYT/PARK-ATP1A3肌张
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渗透泵的植入和压力的诱导，以建立一个症状，药理学小鼠模型DYT/PARK-ATP1A3肌张

Article DOI: 10.3791/61635-v • 10:41 min • September 12th, 2020
September 12th, 2020 •
1, 1, 1, 1
1Department of Neurology, University Hospital of Würzburg

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我们提供一种方案，通过将牙兰膜植入与渗透泵相连的基底神经和小脑，生成药理学 DYT/PARK-ATP1A3 肌张肌小鼠模型。我们描述了通过应用运动挑战来诱导肌张力障碍的运动，以及通过行为评分系统表型的表征。

Tags

神经科学， 问题 163， 神经科学， 药理小鼠模型， 渗透泵， 运动挑战， 压力， 行为特征， 运动障碍， DYT/PARK-ATP1A3， DYT12， 肌张力障碍
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