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Journal / Biology / 与抗原标记阻断病变的复制体遭遇的可视化…
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与抗原标记阻断病变的复制体遭遇的可视化
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Journal (Biology)
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与抗原标记阻断病变的复制体遭遇的可视化

Article DOI: 10.3791/61689-v • 08:24 min • July 27th, 2021
July 27th, 2021 •
*1, *2, 1, 3, 1, 4, 5, 6, 1, 1
1Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, 2Institute of Chemical Biology and Nanomedicine, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology, Hunan University, 3Department of Molecular Biology and Genetics, Cornell University, 4Department of Cellular and Molecular Medicine, University of Copenhagen, 5Horizon Discovery, 6Boston University School of Medicine
* These authors contributed equally

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虽然与DNA加合物的复制叉碰撞可以诱导双链断裂，但对爬酶体和阻断病变之间的相互作用知之甚少。我们采用邻近连接测定来可视化这些遭遇并表征对重复体组成的影响。

Tags

生物学，第 173 期，重复体，阻断病变，PLA，邻近连接测定，DNA 链间交联，抗原标记交联
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