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Journal / Bioengineering / Metabolische profilering om bactericide of…
JoVE Journal
Bioengineering

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JoVE Journal Bioengineering
Metabolische profilering om bactericide of bacteriostatische effecten van nieuwe natuurlijke producten te bepalen met behulp van isothermale microcalorimetrie
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Metabolische profilering om bactericide of bacteriostatische effecten van nieuwe natuurlijke producten te bepalen met behulp van isothermale microcalorimetrie

Article DOI: 10.3791/61703-v • 07:28 min • October 29th, 2020
October 29th, 2020 •
*1,2, *1,2, 1,2, 1,2
1Helmholtz Institute for Pharmaceutical Research Saarland, Department of Microbial Natural Products, Helmholtz Centre for Infection Research and Department of Pharmacy, Saarland University, 2Partner Site Hannover-Braunschweig, German Centre for Infection Research (DZIF)
* These authors contributed equally

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De opheldering van de werkingsmodus van een nieuw antibioticum is een uitdagende taak in het drugsontdekkingsproces. Het doel van de hier beschreven methode is de toepassing van isothermale microcalorimetrie met calScreener in antibacteriële profilering om extra inzicht te geven in interacties tussen geneesmiddelen microbe.

Tags

Bio-engineering Isothermale microcalorimetrie antimicrobiële resistentie natuurlijke producten microbiologie antibacteriële bacteriostatische bactericide Myxobacteria
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