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JoVE Journal Cancer Research
Identification des inhibiteurs de l’EGFR et du SRA à l’aide de Caenorhabditis elegans
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Identification des inhibiteurs de l’EGFR et du SRA à l’aide de Caenorhabditis elegans

Article DOI: 10.3791/61788-v • 08:12 min • October 5th, 2020
October 5th, 2020 •
1,2, 1, 1, 1, 2, 1
1Department of Diagnostic and Biomedical Sciences, School of Dentistry, University of Texas Health Science Center, 2Department of Integrative Biology and Pharmacology, McGovern Medical School, University of Texas Health Science Center

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Le nématode génétiquement traitable Caenorhabditis elegans peut être utilisé comme modèle simple et peu coûteux pour la découverte de médicaments. Décrit ici est un protocole pour identifier les thérapies anticancéreux qui inhibent la signalisation en aval des protéines RAS et EGFR.

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Cancer Research Numéro 164 Caenorhabditis elegans LET-60 LET-23 K-RAS EGFR GFP
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