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Идентификация ингибиторов EGFR и RAS с использованием Caenorhabditis elegans
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Идентификация ингибиторов EGFR и RAS с использованием Caenorhabditis elegans

Article DOI: 10.3791/61788-v • 08:12 min • October 5th, 2020
October 5th, 2020 •
1,2, 1, 1, 1, 2, 1
1Department of Diagnostic and Biomedical Sciences, School of Dentistry, University of Texas Health Science Center, 2Department of Integrative Biology and Pharmacology, McGovern Medical School, University of Texas Health Science Center

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Генетически поддающегося нематоде Caenorhabditis elegans можно использовать в качестве простой и недорогой модели для открытия лекарств. Здесь описан протокол для идентификации противоопухолевых терапевтических средств, которые ингибируют нисходящую передачу сигналов белков RAS и EGFR.

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Исследование рака выпуск 164 Caenorhabditis elegans LET-60 LET-23 K-RAS EGFR GFP
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