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Journal / Bioengineering / Fremstilling af 3D-hjertemikrovævarrays ved hjælp …
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Bioengineering

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JoVE Journal Bioengineering
Fremstilling af 3D-hjertemikrovævarrays ved hjælp af humane iPSC-afledte kardiomyocytter, hjertefibroblaster og endotelceller
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Fremstilling af 3D-hjertemikrovævarrays ved hjælp af humane iPSC-afledte kardiomyocytter, hjertefibroblaster og endotelceller

Article DOI: 10.3791/61879-v • 10:37 min • March 14th, 2021
March 14th, 2021 •
1, 1, 1, 1,2,3
1Stanford Cardiovascular Institute, Stanford University School of Medicine, 2Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, 3Department of Radiology, Stanford University School of Medicine

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Her beskriver vi en brugervenlig metode til at generere 3D-selvmonterede hjertemikrotissue-arrays sammensat af prædifferentierede humaninducerede pluripotente stamcelleafledte kardiomyocytter, hjertefibroblaster og endotelceller. Denne brugervenlige og lavcellekrævende teknik til at generere hjertemikrotiser kan implementeres til sygdomsmodellering og tidlige stadier af lægemiddeludvikling.

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Bioengineering udgave 169 iPSC kardiomyocytter endotelceller fibroblaster mikrovæv selvmontering
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