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Un modello murino singenico di endometriosi utilizzando topi naturalmente ciclabili
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Un modello murino singenico di endometriosi utilizzando topi naturalmente ciclabili

Article DOI: 10.3791/61960-v • 07:12 min • November 24th, 2020
November 24th, 2020 •
*1, *2, 3, 1, 1, 4, 4, 1,5
1Cardiovascular and Metabolic Sciences, Lerner Research Institute; Women’s Health Institute, Cleveland Clinic, 2Women’s Health Institute, Cleveland Clinic, 3Department of Obstetrics and Gynecology, 983255 Nebraska Medical Center, University of Nebraska Medical Center, 4Anatomic Pathology, Cleveland Clinic, 5Gynecologic Oncology, Women’s Health Institute and Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Cleveland Clinic
* These authors contributed equally

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Molti modelli di endometriosi di roditori sono limitati dalla complessità tecnica, dalla riproducibilità e / o dalla necessità di animali immunocompromessi o topi reporter speciali. Presentiamo un sistema semplificato di induzione della lesione utilizzando qualsiasi topo sperimentale con un sistema di punteggio oggettivo verificabile in modo indipendente e senza necessità di ovariectomia o chirurgia di sopravvivenza.

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Medicina Numero 165 endometriosi modello animale singeneico murino mestruazioni retrograde endometrio
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