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Journal / Bioengineering / Hjertesfæroider som in vitro bioingeniør…
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Bioengineering
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JoVE Journal Bioengineering
Hjertesfæroider som in vitro bioingeniør hjertevev for å studere humant hjerte patofysiologi
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Hjertesfæroider som in vitro bioingeniør hjertevev for å studere humant hjerte patofysiologi

Article DOI: 10.3791/61962-v • 10:41 min • January 23rd, 2021
January 23rd, 2021 •
1,2,3,4, 2,3,4
1University of Newcastle, 2University of Sydney, 3Kolling Institute of Medical Research, Royal North Shore Hospital, 4University of Technology, Sydney

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Denne protokollen tar sikte på å fremstille 3D hjertesfæroider (CSs) ved å co-culturing celler i hengende dråper. Kollagen-innebygde CSs behandles med doksorubicin (DOX, et kardiotoksisk middel) ved fysiologiske konsentrasjoner for å modellere hjertesvikt. In vitro-testing med DOX-behandlede CS-er kan brukes til å identifisere nye behandlinger for hjertesviktpasienter.

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Bioengineering Vaskulariserte hjertesfæroider bioingeniør hjertevev vaskularisering 3D-kokulturer stamceller kardiomyocytter fibroblaster endotelceller in vitro-testing doksorubicin kardiotoksisitet.
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