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Journal / Bioengineering / Cardiac Sfæroider som in vitro Bioengineered…
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Bioengineering
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JoVE Journal Bioengineering
Cardiac Sfæroider som in vitro Bioengineered hjertevæv at studere Human Heart Patofysiologi
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Cardiac Sfæroider som in vitro Bioengineered hjertevæv at studere Human Heart Patofysiologi

Article DOI: 10.3791/61962-v • 10:41 min • January 23rd, 2021
January 23rd, 2021 •
1,2,3,4, 2,3,4
1University of Newcastle, 2University of Sydney, 3Kolling Institute of Medical Research, Royal North Shore Hospital, 4University of Technology, Sydney

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Denne protokol har til formål at fremstille 3D hjerte sfæroider (CSs) ved co-dyrkning celler i hængende dråber. Kollagen-indlejrede CS'er behandles med doxorubicin (DOX, et kardiotoksisk middel) ved fysiologiske koncentrationer for at modellere hjertesvigt. In vitro-test ved hjælp af DOX-behandlede CS'er kan anvendes til at identificere nye behandlinger for hjertesvigt patienter.

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Bioengineering Vaskulære hjerte sfæroider bioengineered hjerte væv vaskulærisering 3D co-kulturer stamceller kardiomyocytter fibroblaster endotelceller in vitro-test doxorubicin kardiotoksicitet.
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