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JoVE Journal Bioengineering
Modelo microfluídico para imitar el evento inicial de neovascularización
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Modelo microfluídico para imitar el evento inicial de neovascularización

Article DOI: 10.3791/62003-v • 10:01 min • April 10th, 2021
April 10th, 2021 •
1, 1, 1, 4, 1, 1, 1, 3, 1,2
1Beijing Advanced Innovation Centre for Biomedical Engineering, Key Laboratory for Biomechanics and Mechanobiology of Chinese Education Ministry, School of Biological Science and Medical Engineering, Beihang University, 2School of Engineering Medicine, Beihang University, 3Artificial Intelligence Key Laboratory of Sichuan Province, School of Automation and Information Engineering, Sichuan University of Science and Engineering, 4Beijing Research Center of Urban System Engineering

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Aquí, proporcionamos un chip microfluídico y un sistema microfluídico de circulación automáticamente controlado y altamente eficiente que recapitula el microambiente inicial de neovascularización, permitiendo que las células endoteliales (ECs) sean estimuladas por un alto estrés esquilar luminal, nivel fisiológico de flujo transendotelial y diversa distribución del factor de crecimiento endotelial vascular (VEGF) simultáneamente.

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Bioingeniería Número 170 neovascularización microfluídica estrés cizallador microambiente flujo transendotelial cultivo 3D
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