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Cardiale respons op β-adrenerge stimulatie bepaald door druk-volume lusanalyse
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Cardiale respons op β-adrenerge stimulatie bepaald door druk-volume lusanalyse

Article DOI: 10.3791/62057-v • 08:05 min • May 19th, 2021
May 19th, 2021 •
*1,2, *1,2,3, *1,2,4, 1,2, 1,2
1Pharmakologisches Institut, Ruprecht-Karls-Universität Heidelberg, 2DZHK (German Centre for Cardiovascular Research), partner site Heidelberg/Mannheim, 3Department of Internal Medicine III, University of Heidelberg, 4Department of Anesthesiology, University Hospital RWTH Aachen
* These authors contributed equally

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Hier beschrijven we een cardiale druk-volume lusanalyse onder toenemende doses intraveneus geïnfundeerd isoproterenol om de intrinsieke hartfunctie en de β-adrenerge reserve bij muizen te bepalen. We gebruiken een aangepaste open-borstbenadering voor de druk-volume lusmetingen, waarbij we ventilatie met positieve eind-expiratoire druk opnemen.

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Geneeskunde Nummer 171 β-adrenerge stimulatie isoproterenol hartfunctie Druk-Volume Loops hart muis in vivo open-borst
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