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Organoidafledt epitelmonolag: En klinisk relevant in vitro-model til tarmbarrierefunktion

Article DOI: 10.3791/62074-v • 09:40 min • July 29th, 2021
July 29th, 2021 •
1, 1, 1, 1, 1, 1, 1, 1
1Foundation Hubrecht Organoid Technology (HUB)

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Her beskriver vi forberedelsen af humane organoidafledte tarmepitelmonolag til undersøgelse af tarmbarrierefunktion, permeabilitet og transport. Da organoider repræsenterer originalt epitelvævsrespons på eksterne stimuli, kombinerer disse modeller fordelene ved udvidelighed af cellelinjer og relevansen og kompleksiteten af primært væv.

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Biologi udgave 173 epitelmonolag humane tarmorganoider membranindsats barrierefunktion permeabilitet transport
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