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Bioengineering

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JoVE Journal Bioengineering
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Multi-timescale mikroskopi metoder til karakterisering af fluorescerende-mærket Microbubbles for Ultralyd-udløst Drug Release

Article DOI: 10.3791/62251-v • 06:02 min • June 12th, 2021
June 12th, 2021 •
1, 1,2, 1, 3, 4,5,6, 3,6,7, 7, 1
1Physics of Fluids group, Department of Science and Technology, MESA+ Institute for Nanotechnology and Technical Medical (TechMed) Center, University of Twente, 2BIOS Lab-on-a-Chip group, Max Planck Center Twente for Complex Fluid Dynamics, MESA+ Institute for Nanotechnology and Technical Medical (TechMed) Center, University of Twente, 3Department of Biotechnology and Nanomedicine, SINTEF Industry, 4Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, 5Department of Health Research, SINTEF Digital, 6Cancer Clinic, St. Olav’s Hospital, 7Department of Physics, Norwegian University of Science and Technology

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De præsenterede protokoller kan bruges til at karakterisere reaktionen af fluorescerende-mærket mikrobobler designet til ultralyd-udløste lægemiddellevering applikationer, herunder deres aktiveringsmekanismer samt deres biovirkninger. Dette papir dækker en række in vitro - og in vivomikroskopiteknikker , der udføres for at fange de relevante længder og tidshorisonter.

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Bioengineering ultralyd ultralyd kontrast midler lægemiddellevering bright-field mikroskopi fluorescens mikroskopi intravital mikroskopi konfokal mikroskopi
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