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Journal / Biochemistry / NMR-basert fragmentscreening i et minimumsutvalg, …
JoVE Journal
Biochemistry

This content is Open Access.

JoVE Journal Biochemistry
NMR-basert fragmentscreening i et minimumsutvalg, men maksimal automatiseringsmodus
Measurement of Protein Import Capacity of Skeletal Muscle Mitochondria
Journal (Biochemistry)
Measurement of Protein Import Capacity of Skeletal Muscle Mitochondria
Workflow and Tools for Crystallographic Fragment Screening at the Helmholtz-Zentrum Berlin
Journal (Biochemistry)
Workflow and Tools for Crystallographic Fragment Screening at the Helmholtz-Zentrum Berlin
 
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NMR-basert fragmentscreening i et minimumsutvalg, men maksimal automatiseringsmodus

Article DOI: 10.3791/62262-v • 09:19 min • June 4th, 2021
June 4th, 2021 •
*1, *1, 1,2, 1, 1, 1,2
1Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance (BMRZ), Johann Wolfgang Goethe-University Frankfurt, 2German Cancer Consortium (DKTK) and DKFZ
* These authors contributed equally

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Fragmentbasert screening av NMR er en robust metode for raskt å identifisere små molekylbindemidler til biomakromolekyler (DNA, RNA eller proteiner). Protokoller som beskriver automatiseringsbasert prøvepreparering, NMR-eksperimenter og innsamlingsbetingelser og analysearbeidsflyter presenteres. Teknikken muliggjør optimal utnyttelse av både 1H og 19F NMR-aktive kjerner for deteksjon.

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Denne måneden i JoVE utgave 172 Fragmentbasert screening Automatisering Løsning NMR-spektroskopi Datainnsamling og analyse Screeningplattform Fragmentbibliotek
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