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Journal / Developmental Biology / Generierung von 3D-Ganzlungenorganoiden aus…
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JoVE Journal Developmental Biology
Generierung von 3D-Ganzlungenorganoiden aus induzierten pluripotenten Stammzellen zur Modellierung der Lungenentwicklungsbiologie und -krankheit
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Generierung von 3D-Ganzlungenorganoiden aus induzierten pluripotenten Stammzellen zur Modellierung der Lungenentwicklungsbiologie und -krankheit

Article DOI: 10.3791/62456-v • 09:45 min • April 12th, 2021
April 12th, 2021 •
1,2,3, 2,3, 2,3, 1,2,3
1Department of Pediatrics, University of California, San Diego School of Medicine, 2Sanford Consortium for Regenerative Medicine, 3Sanford Burnham Prebys Medical Discovery Institute

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Der Artikel beschreibt die schrittweise gerichtete Differenzierung von induzierten pluripotenten Stammzellen zu dreidimensionalen ganzen Lungenorganoiden, die sowohl proximale als auch distale epitheliale Lungenzellen zusammen mit Mesenchym enthalten.

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Entwicklungsbiologie Ausgabe 170 humane pluripotente Stammzellen Endoderm Lungenvorläuferzellen 3D-Ganzlungenorganoide Lungenepithelzellen Lungenmesenchymzellen Lungenentwicklung Lungenerkrankungsmodellierung
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