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Cancer Research

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Portal Vein Injection of Colorectal Cancer Organoids to Study the Liver Metastasis Stroma
 

Portal Vein Injection of Colorectal Cancer Organoids to Study the Liver Metastasis Stroma

Article DOI: 10.3791/62630-v
September 3rd, 2021

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Summary September 3rd, 2021

Portal vein injection of colorectal cancer (CRC) organoids generates stroma-rich liver metastasis. This mouse model of CRC hepatic metastasis represents a useful tool to study tumor-stroma interactions and develop novel stroma-directed therapeutics such as adeno-associated virus-mediated gene therapies.

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