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JoVE Journal Bioengineering
Spatio-Temporal In Vivo Imaging of Ocular Drug Delivery Systems using Fiberoptic Confocal Laser Microendoscopy
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Spatio-Temporal In Vivo Imaging of Ocular Drug Delivery Systems using Fiberoptic Confocal Laser Microendoscopy

Article DOI: 10.3791/62685-v • 07:12 min • September 27th, 2021
September 27th, 2021 •
1,2, 3,4, 2,5, 1
1Laboratory for Translational and Molecular Imaging, Cancer and Stem Cell Biology Programme, Duke-NUS Medical School, 2School of Materials Science and Engineering, Nanyang Technological University, 3Singapore National Eye Centre, 4Singapore Eye Research Institute, 5Material Science & Engineering, National University of Singapore

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Summary
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We present a protocol for the use of fiberoptic confocal laser microendoscopy (CLM) to non-invasively study the spatio-temporal distribution of liposomes in the eye after subconjunctival injection.

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Spatio-Temporal In Vivo Imaging Ocular Drug Delivery Systems Fiberoptic Confocal Laser Microendoscopy Screening Formulations Tissue Residence Times Drug Delivery System Noninvasive Imaging Realtime Imaging Nano-carrier Cancer Treatment Infectious Disease Treatment Subconjunctival Injection Evans Blue Sedation Heating Pad Proxymetacaine Hydrochloride Solution Fluorescent Liposomes Subconjunctival Space
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