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JoVE Journal Bioengineering
A Large Animal Model for Pulmonary Hypertension and Right Ventricular Failure
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A Large Animal Model for Pulmonary Hypertension and Right Ventricular Failure: Left Pulmonary Artery Ligation and Progressive Main Pulmonary Artery Banding in Sheep

Article DOI: 10.3791/62694-v • 07:02 min • July 15th, 2021
July 15th, 2021 •
1, 1, 1, 1, 1, 1, 5, 1, 3, 2, 4, 1,6
1Department of Thoracic Surgery, Vanderbilt University Medical Center, 2Department of Biomedical Engineering, Carnegie Mellon University, 3Department of Pediatrics, Columbia University Medical Center, Columbia University Irving Medical Center, 4Department of Medicine, Columbia University Medical Center, Columbia University Irving Medical Center, 5Department of Anesthesiology, Vanderbilt University Medical Center, 6Department of Biomedical Engineering, Vanderbilt University

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Summary
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This manuscript describes the surgical technique and experimental approach to develop severe right ventricular pressure overload to model their adaptive and maladaptive phenotypes.

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Large Animal Model Pulmonary Hypertension Right Ventricular Failure Left Pulmonary Artery Ligation Progressive Main Pulmonary Artery Banding Sheep RV-targeted Therapeutics RV Adaptation Control Over RV Phenotype Dr. Matthew Bacchetta Surgical Fellows John Stokes Kelly Wu Yatrik Patel Anesthetization Surgical Field Muscle Sparing Mini Thoracotomy Incision Length Finochietto Retractor Intercostal Space
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