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JoVE Journal Neuroscience
Generazione di organoidi del cervello umano per la modellazione della malattia mitocondriale
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Generazione di organoidi del cervello umano per la modellazione della malattia mitocondriale

Article DOI: 10.3791/62756-v • 08:09 min • June 21st, 2021
June 21st, 2021 •
1, 2, 1,4, 1, 2, 3, 3, 2, 1,5
1Department of General Pediatrics, Neonatology and Pediatric Cardiology, Duesseldorf University Hospital, Medical Faculty, Heinrich Heine University, 2Institute of Neurobiology, Heinrich Heine University, 3Berlin Institute for Medical Systems Biology (BIMSB), Max Delbrueck Center for Molecular Medicine (MDC), 4Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, 5Max Delbrueck Center for Molecular Medicine (MDC)

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Descriviamo un protocollo dettagliato per la generazione di organoidi cerebrali derivati da cellule staminali pluripotenti indotte dall'uomo e il loro uso nella modellazione delle malattie mitocondriali.

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Neuroscienze Numero 172 organoidi cerebrali iPSC malattia mitocondriale profilazione bioenergetica
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