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JoVE Journal Bioengineering
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Platelet-Derived Extracellular Vesicle Functionalization of Ti Implants

Article DOI: 10.3791/62781-v • 04:16 min • August 5th, 2021
August 5th, 2021 •
1,2, 1,2, 1,2,3, 1,2,3, 1,2,4, 1,2,4
1Cell Therapy and Tissue Engineering Group, Research Institute on Health Sciences (IUNICS), University of the Balearic Islands, 2Health Research Institute of the Balearic Islands (IdISBa), 3Fundació Banc de Sang i Teixits de les Illes Balears (FBSTIB), 4Department of Fundamental Biology and Health Sciences, University of the Balearic Islands

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Summary
Automatic Translation

Here, we present a method for the isolation of Extracellular Vesicles (EVs) derived from the platelet lysates (PL) and their use for coating titanium (Ti) implant surfaces. We describe the drop casting coating method, the EVs release profile from the surfaces, and in vitro biocompatibility of EVs coated Ti surfaces.

Tags

Platelet-derived Extracellular Vesicles Ti Implants Functionalization Regenerative Medicine Orthopedics Bone Regeneration Drop Casting Low-cost Method Titanium Surface Functionalization Washing Sonication Sodium Hydroxide Solution Nitric Acid Solution Washes PH Indicator
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