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Induction and Assessment of Levodopa-induced Dyskinesias in a Rat Model of Parkinson's Disease
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Induction and Assessment of Levodopa-induced Dyskinesias in a Rat Model of Parkinson's Disease

Article DOI: 10.3791/62970-v • 05:51 min • October 14th, 2021
October 14th, 2021 •
1, 1, 1,2
1Department of Translational Neuroscience, College of Human Medicine, Michigan State University, 2Hauenstein Neuroscience Center, Mercy Health Saint Mary's

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Summary
Automatic Translation

This article describes methods to induce and evaluate levodopa-induced dyskinesias in a rat model of Parkinson's disease. The protocol offers detailed information regarding the intensity and frequency of a range of dyskinetic behaviors, both dystonic and hyperkinetic, providing a reliable tool to test treatments targeting this unmet medical need.

Tags

Induction Assessment Levodopa-induced Dyskinesias Rat Model Parkinson's Disease Protocol Reliable Method Comprehensive Rating Dyskinesia Rating Scale Abnormal Involuntary Movement Time Quantification Animal Models Effective Treatments Side Effect Preparation Experiment Weighing Rats Drug Quantity Nutritionally Complete Treats Single Housing Behavioral Assessments Water Bottles Food Racks Enrichment Cage Placement Identification Tags L-DOPA Injection
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