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JoVE Journal Cancer Research
A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis
Introducing Human Cells into a Microfluidic Device to Investigate Tumor Progression in a Vascularized Micro-Tumor System
Journal (Cancer Research)
Introducing Human Cells into a Microfluidic Device to Investigate Tumor Progression in a Vascularized Micro-Tumor System
Cytometer Assays of MPNST Cells Challenged with Therapeutic Agents
Journal (Cancer Research)
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A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

Article DOI: 10.3791/63186-v • 07:41 min • March 8th, 2022
March 8th, 2022 •
1,2, 1,2, 1,2, 1,2, 1,2, 1,2, 3,4, 2,5, 3,4, 1,2
1Department of Pathology, NYU Grossman School of Medicine, 2Interdisciplinary Melanoma Cooperative Group, Perlmutter Cancer Center, 3Department of Radiology, NYU Grossman School of Medicine, 4Preclinical Imaging Core, NYU Grossman School of Medicine, 5Ronald Perelman Department of Dermatology, NYU Grossman School of Medicine

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Summary
Automatic Translation

This article describes a workflow of techniques employed for testing novel candidate mediators of melanoma metastasis and their mechanism(s) of action.

Tags

Robust Discovery Platform Identification Of Novel Mediators Melanoma Metastasis In Vivo Effects Candidate Regulators Solid Malignancies Reproducibility Standardized Models Target Discovery Therapy Development Omics Data In Vitro Assays Learning Curve Materials Provided Detailed Description Intradermal Injections Anesthetize Biosafety Cabinet Aseptic Conditions Skin Puncture Insulin Syringe Needle Tumor Cell Suspension Tumor Growth
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