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JoVE Journal Cancer Research
Culture of Bladder Cancer Organoids as Precision Medicine Tools
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Culture of Bladder Cancer Organoids as Precision Medicine Tools

Article DOI: 10.3791/63192-v • 08:39 min • December 28th, 2021
December 28th, 2021 •
1,2,3,4, 1,2,3,4,5, 1,4, 1,4,5, 1,2, 1,2, 1,2,4, 1,2,3,4, 1,2,3, 1,2, 1,2, 1,2,3,4, *1,2,3,4,5, *1,2,3,4
1School of Biomedical Sciences, Faculty of Health, Queensland University of Technology (QUT) at Translational Research Institute, 2Queensland Bladder Cancer Initiative (QBCI), 3Centre for Personalised Analysis of Cancers (CPAC), 4Australian Prostate Cancer Research Centre - Queensland, 5Department of Urology, Princess Alexandra Hospital
* These authors contributed equally

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Summary
Automatic Translation

Patient-derived organoids (PDOs) are a powerful tool in translational cancer research, reflecting both the genetic and phenotypic heterogeneity of the disease and response to personalized anti-cancer therapies. Here, a consolidated protocol to generate human primary bladder cancer PDOs in preparation for the evaluation of phenotypic analyses and drug responses is detailed.

Tags

Bladder Cancer Organoids Precision Medicine Urological Cancers Genetic Heterogeneity Phenotypic Heterogeneity Patient Biopsy Downstream Analysis Cellular Basis Molecular Basis Treatments Individual Patients Cancer Tumor Specimen Transport Medium Basal Media Petri Dish Dissection Grid
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