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Visualizing and Quantifying Pharmaceutical Compounds within Skin using Coherent Raman Scattering Imaging
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Visualizing and Quantifying Pharmaceutical Compounds within Skin using Coherent Raman Scattering Imaging

Article DOI: 10.3791/63264-v • 11:07 min • November 24th, 2021
November 24th, 2021 •
1, 1, 1, 1
1Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School

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Summary
Automatic Translation

A coherent Raman scattering imaging methodology to visualize and quantify pharmaceutical compounds within the skin is described. This paper describes skin tissue preparation (human and mouse) and topical formulation application, image acquisition to quantify spatiotemporal concentration profiles, and preliminary pharmacokinetic analysis to assess topical drug delivery.

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Visualizing Quantifying Pharmaceutical Compounds Skin Coherent Raman Scattering Imaging Reproducible Method Accurate Method Quantify Topically-applied Drug Products Coherent Raman Imaging Cutaneous Pharmacokinetic Information Permeation Pathways Target Site Tissue Preparation Nude Mouse Ear Skin Tissue Petri Dish PBS Task Wiper Harvesting
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